Drug Interactions
Phentermine should not be taken with drugs called monoamine oxidase inhibitors such as selegiline (Eldepryl), tranylcypromine (Parnate), and phenelzine (Nardil) that are used to treat depression and Parkinson’s disease. You should not take Phentermine with other prescription weight loss drugs like sibutramine (Meridia). Consult your physician before taking Phentermine with other over-the-counter or herbal weight loss drugs.

It is important to inform your doctor about all other medications being taken prior to taking Phentermine. Your doctor may conclude that Phentermine should not be taken while using a particular medication, or may decide to alter the dosage of either Phentermine or the other medication when the two are taken together. Certain medications may cause complications when taken at the same time as Phentermine. These include:

• Amantadine (example - Symmetrel)
• Amphetamines
• Caffeine (example - cold medications)
• Chlophedianol (example - Ulone)
• Cocaine
• Asthma and other breathing medications
• Cold, sinus and allergy medications
• Methylphenidate (example - Ritalin)
• Nabilone (example - Cesamet)
• Pemoline (example - Cylert)
• Appetite suppressants (example - other diet pills)
• Selective serotonin reuptake inhibitors (example - citalopram (Celexa), fluoxetine (Prozac), fluvoxamine (Luvox), paroxetine (Paxil), sertraline (Zoloft)
• Monoamine oxidase (MAO) inhibitor activity (example - isocarboxazid (Marplan), isocarboxazid (Marplan), phenelzine (Nardil), procarbazine (Matulane), selegiline (Eldepryl), tranylcypromine (Parnate)
• Tricyclic antidepressants (example - amitriptyline (Elavil), amoxapine (Asendin), clomipramine (Anafranil), desipramine (Pertofrane), doxepin (Sinequan), imipramine (Tofranil), nortriptyline (Aventyl), protriptyline (Vivactil), trimipramine (Surmontil)

Do not take Phentermine if you've previously experienced an allergic reaction to Phentermine or any other sympathomimetic appetite suppressant. Inform your doctor, prior to taking Phentermine, if you have had allergic reactions to any of the following drugs: amphetamine, dextroamphetamine, ephedrine, epinephrine, isoproterenol, norepinephrine, phenylephrine, metaproterenol, methamphetamine, phenylpropanolamine,
pseudoephedrine, or terbutaline.

Whenever two or more drugs are taken concurrently, there is a chance that there will be an interaction among the drugs. The interaction may increase or decrease the effectiveness and/or the side effects of the drugs. It also may result in a new side effect, that is, a side effect not seen with the use of any one drug alone. The likelihood of drug interactions increases as the number of drugs being taken by a patient increases. Therefore, people who take several medications are at the greatest risk for interactions. Drug interactions contribute to the cost of healthcare because of the medical care costs that are required to treat them. Interactions can also lead to pain and suffering that could be avoided. This month's topic discusses the issue of drug interactions and several ways to avoid them.